What is The Latest Treatment for Nasal Polyps ? ( Study )


The presenting symptoms of nasal disorders such as allergic rhinitis, chronic rhinosinusitis with nasal polyps, and aspirin-induced asthma include nasal discharge and nasal congestion, which are responsible for not only decreasing quality of life, but also impeding the activities of daily living. 

These pathological conditions, which lead to mucus overproduction and edema in the nasal mucosa, might be precipitated by the actions of molecules such
as pendrin and pe- riostin. Periostin is an extracellular matrix protein originally isolated from an osteoblast cell line; its production is induced by IL-4 and IL-13 in airway epithelial cells.Periostin is also a regulator of fibrosis and collagen deposition, and although it has been recognized for its important role in myocardial repair and remodeling following myocardial infarction,2 its over-production in the nasal mucosa has been reported to contribute to polyp formation.  Although we know that pendrin is genetically associated with Pendred syndrome, pendrin has recently been found to induce increased mucus production in airway epithelial cells, suggesting its potential involvement in asthma- induced airway inflammation and occlusion.

In recent study, surgical samples were investigated by means of real-time reverse transcription-polymerase chain reaction to evaluate the expression of pendrin and periostin mRNA. The presence and location of pendrin and periostin were determined by immunohistochemistry and Western blotting.


Results: Pendrin and periostin production was significantly higher in patients with nasal disorders than in controls. Further significant increases in periostin expression were noted in patients with chronic rhinosinusitis with nasal polyps and in those with aspirin-induced asthma.

Production of pendrin and periostin is upregulated in allergic rhinitis, chronic rhinosinusitis with nasal polyps, and aspirin-induced asthma. These findings suggest that pendrin can induce mucus production and that periostin can induce tissue fibrosis and remodeling in the nasal mucosa. Therefore, these mediators may be therapeutic target candidates for allergic rhinitis, chronic rhinosinusitis with nasal polyps, and aspirin- induced asthma. Thus, natural treatment may be the next way to get rid of nasal polyps.

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